Arizona vs. Seattle – Betting Preview & Best Props
📅 Date: September 25th, 2025
📍 Location: State Farm Stadium (Glendale, AZ)
📺 Broadcast: Prime Video, NFL+
Betting Odds (as of September 25th)
- Spread: Arizona +1.5 / Seattle -1.5
- Moneyline: Arizona +110 / Seattle -130
- Total (O/U): 43.5 Points
(Odds via DK, Fanduel, BetMGM, subject to change)
Arizona
- Strengths/Pros:
- Trey Mcbride is still producing (not as much as 2024) – Expect an uptick in his volume after the Conner injury.
- Kyler Murray has looked good – Just needs to put it all together.
- Weaknesses/Cons:
- No James Conner, Marvin Harrison Jr. Drops.
- Offensive line is beat up.
- Offense has only two touchdown passes in the last 10 quarters.
Seattle
- Strengths/Pros:
- Defense has glimmers of the Seattle defenses in the early 2010’s.
- Defense allowing under 15.7 points/game (second fewest).
- Opened as the underdog – Are now the favorite.
- Weaknesses/Cons:
- The run game hasn’t been as productive (ranked 21st).
- Passing yards allowed (ranked 20th) – Expect a heavy focus on Trey Mcbride/ Marvin Harrison Jr.
Key Betting Trends
- Arizona is 2-1 ATS in their last 3 games.
- Arizona has hit the over once this year.
- Seattle has hit the over twice this year.
- Seattle is 2-1 ATS in their last 3 games.
Prop Bets to Watch
- QB Sam Darnold Passing Yards – [Over 220+]
- Why: Arizona defense is ranked 30th in pass yards allowed.
- RB Kenneth Walker Rushing TD – [+105]
- Why: Arizona is going to focus heavy on their weak pass defense. Kenneth Walker is primed to take advantage of that.
- Anytime TD Scorer – Trey Mcbride (+175)
- Why: His volume has increased and with no James Conner – Look out for Mcbride to be the redzone threat.
The Buzz Take
- Arizona is beat up, the spread has moved to favor Seattle. If this game was in Seattle it would be a no brainer.
- If you expect a shootout, the Over and WR receiving props are worth a look.
Lean: Seattle -1.5 + Kenneth Walker anytime TD]
Best Bet Recommendation
👉 Seattle ML
👉 Kenneth Walker/ Trey Mcbride anytime TD
